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BICOB
2011
Springer
12 years 4 months ago
Similarity and Prioritization of Disease Proteins using Path Length Measure
Semantic similarity measures have been used successfully and extensively in the biomedical research with various applications. As the biomedical ontologies, which form the main gro...
Anurag Nagar, Hisham Al-Mubaid
BMCBI
2010
146views more  BMCBI 2010»
13 years 4 months ago
Revealing and avoiding bias in semantic similarity scores for protein pairs
Background: Semantic similarity scores for protein pairs are widely applied in functional genomic researches for finding functional clusters of proteins, predicting protein functi...
Jing Wang 0004, Xianxiao Zhou, Jing Zhu, Chenggui ...
JAMIA
2011
94views more  JAMIA 2011»
12 years 7 months ago
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence
Objective Uncovering the dominant molecular deregulation among the multitude of pathways implicated in aggressive prostate cancer is essential to intelligently developing targeted...
James L. Chen, Jianrong Li, Walter M. Stadler, Yve...
BMCBI
2006
117views more  BMCBI 2006»
13 years 4 months ago
SigFlux: A novel network feature to evaluate the importance of proteins in signal transduction networks
Background: Measuring each protein's importance in signaling networks helps to identify the crucial proteins in a cellular process, find the fragile portion of the biology sy...
Wei Liu, Dong Li, Jiyang Zhang, Yunping Zhu, Fuchu...