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BMCBI
2007
130views more  BMCBI 2007»
13 years 5 months ago
HMM-ModE - Improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying e
Background: Profile Hidden Markov Models (HMM) are statistical representations of protein families derived from patterns of sequence conservation in multiple alignments and have b...
Prashant K. Srivastava, Dhwani K. Desai, Soumyadee...
BMCBI
2006
143views more  BMCBI 2006»
13 years 5 months ago
Application of protein structure alignments to iterated hidden Markov model protocols for structure prediction
Background: One of the most powerful methods for the prediction of protein structure from sequence information alone is the iterative construction of profile-type models. Because ...
Eric D. Scheeff, Philip E. Bourne
BMCBI
2004
208views more  BMCBI 2004»
13 years 4 months ago
Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Vadim Alexandrov, Mark Gerstein
GCB
2000
Springer
137views Biometrics» more  GCB 2000»
13 years 8 months ago
Detecting Sporadic Recombination in DNA Alignments with Hidden Markov Models
Conventional phylogenetic tree estimation methods assume that all sites in a DNA multiple alignment have the same evolutionary history. This assumption is violated in data sets fro...
Dirk Husmeier, Frank Wright