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BMCBI
2004
139views more  BMCBI 2004»
13 years 5 months ago
Resolution of large and small differences in gene expression using models for the Bayesian analysis of gene expression levels an
Background: The detection of small yet statistically significant differences in gene expression in spotted DNA microarray studies is an ongoing challenge. Meeting this challenge r...
Jeffrey P. Townsend
BMCBI
2004
150views more  BMCBI 2004»
13 years 5 months ago
Rank Difference Analysis of Microarrays (RDAM), a novel approach to statistical analysis of microarray expression profiling data
Background: A key step in the analysis of microarray expression profiling data is the identification of genes that display statistically significant changes in expression signals ...
Dietmar E. Martin, Philippe Demougin, Michael N. H...
BMCBI
2007
148views more  BMCBI 2007»
13 years 5 months ago
Computation of significance scores of unweighted Gene Set Enrichment Analyses
Background: Gene Set Enrichment Analysis (GSEA) is a computational method for the statistical evaluation of sorted lists of genes or proteins. Originally GSEA was developed for in...
Andreas Keller, Christina Backes, Hans-Peter Lenho...
BMCBI
2005
113views more  BMCBI 2005»
13 years 5 months ago
Normal uniform mixture differential gene expression detection for cDNA microarrays
Background: One of the primary tasks in analysing gene expression data is finding genes that are differentially expressed in different samples. Multiple testing issues due to the ...
Nema Dean, Adrian E. Raftery
BMCBI
2005
140views more  BMCBI 2005»
13 years 5 months ago
Dissecting systems-wide data using mixture models: application to identify affected cellular processes
Background: Functional analysis of data from genome-scale experiments, such as microarrays, requires an extensive selection of differentially expressed genes. Under many condition...
J. Peter Svensson, Renée X. de Menezes, Ing...