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RECOMB
1999
Springer
13 years 8 months ago
Classifying proteins by family using the product of correlated p-values
An important goal in bioinformatics is determining the homology and function of proteins from their sequences. Pairwise sequence similarity algorithms are often employed for this ...
Timothy L. Bailey, William Noble Grundy
RECOMB
2004
Springer
14 years 4 months ago
The evolutionary capacity of protein structures
In nature, one finds large collections of different protein sequences exhibiting roughly the same three-dimensional structure, and this observation underpins the study of structur...
Leonid Meyerguz, David Kempe, Jon M. Kleinberg, Ro...
BMCBI
2008
108views more  BMCBI 2008»
13 years 4 months ago
A nonparametric model for quality control of database search results in shotgun proteomics
Background: Analysis of complex samples with tandem mass spectrometry (MS/MS) has become routine in proteomic research. However, validation of database search results creates a bo...
Jiyang Zhang, Jianqi Li, Xin Liu, Hongwei Xie, Yun...
BMCBI
2007
147views more  BMCBI 2007»
13 years 4 months ago
Hon-yaku: a biology-driven Bayesian methodology for identifying translation initiation sites in prokaryotes
Background: Computational prediction methods are currently used to identify genes in prokaryote genomes. However, identification of the correct translation initiation sites remain...
Yuko Makita, Michiel J. L. de Hoon, Antoine Danchi...
BMCBI
2006
137views more  BMCBI 2006»
13 years 4 months ago
Bounded search for de novo identification of degenerate cis-regulatory elements
Background: The identification of statistically overrepresented sequences in the upstream regions of coregulated genes should theoretically permit the identification of potential ...
Jonathan M. Carlson, Arijit Chakravarty, Radhika S...