34 search results - page 5 / 7 » Suboptimal Alignments Improve the Detection of Weak Homologs... |
BMCBI
2010
13 years 5 months ago
2010
Background: Determining beforehand specific positions to align (anchor points) has proved valuable for the accuracy of automated multiple sequence alignment (MSA) software. This f...
BMCBI
2011
13 years 8 days ago
2011
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
BMCBI
2007
13 years 5 months ago
2007
Background: To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching s...
BMCBI
2008
13 years 5 months ago
2008
Background: The conservation of gene order among prokaryotic genomes can provide valuable insight into gene function, protein interactions, or events by which genomes have evolved...
NAR
1998
13 years 4 months ago
1998
The Protein Information Resource (PIR; http://wwwnbrf.georgetown.edu/pir/ ) supports research on molecular evolution, functional genomics, and computational biology by maintaining...