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BMCBI
2010
159views more  BMCBI 2010»
13 years 5 months ago
Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines
Background: Protein-protein interaction (PPI) plays essential roles in cellular functions. The cost, time and other limitations associated with the current experimental methods ha...
Alvaro J. González, Li Liao
BMCBI
2004
135views more  BMCBI 2004»
13 years 5 months ago
Information assessment on predicting protein-protein interactions
Background: Identifying protein-protein interactions is fundamental for understanding the molecular machinery of the cell. Proteome-wide studies of protein-protein interactions ar...
Nan Lin, Baolin Wu, Ronald Jansen, Mark Gerstein, ...
BMCBI
2010
113views more  BMCBI 2010»
13 years 5 months ago
Class prediction for high-dimensional class-imbalanced data
Background: The goal of class prediction studies is to develop rules to accurately predict the class membership of new samples. The rules are derived using the values of the varia...
Rok Blagus, Lara Lusa
BMCBI
2008
102views more  BMCBI 2008»
13 years 5 months ago
Improving protein function prediction methods with integrated literature data
Background: Determining the function of uncharacterized proteins is a major challenge in the post-genomic era due to the problem's complexity and scale. Identifying a protein...
Aaron Gabow, Sonia M. Leach, William A. Baumgartne...
BMCBI
2010
122views more  BMCBI 2010»
13 years 23 days ago
Functional enrichment analyses and construction of functional similarity networks with high confidence function prediction by PF
Background: A new paradigm of biological investigation takes advantage of technologies that produce large high throughput datasets, including genome sequences, interactions of pro...
Troy Hawkins, Meghana Chitale, Daisuke Kihara