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BIOINFORMATICS
2012
11 years 8 months ago
Epigenetic priors for identifying active transcription factor binding sites
Motivation Accurate knowledge of the genome-wide binding of transcription factors in a particular cell type or under a particular condition is necessary for understanding transcri...
Gabriel Cuellar-Partida, Fabian A. Buske, Robert C...
STOC
2009
ACM
271views Algorithms» more  STOC 2009»
14 years 6 months ago
A fast and efficient algorithm for low-rank approximation of a matrix
The low-rank matrix approximation problem involves finding of a rank k version of a m ? n matrix AAA, labeled AAAk, such that AAAk is as "close" as possible to the best ...
Nam H. Nguyen, Thong T. Do, Trac D. Tran
DAC
1999
ACM
13 years 10 months ago
Panel: What is the Proper System on Chip Design Methodology
ion model or flexible PCB solutions cannot offer a valid solution for the next millinium SoCs . James G. Dougherty, Integrated Systems Silicon LTD, Belfast, Northern Ireland ISS an...
Richard Goering, Pierre Bricaud, James G. Doughert...
BMCBI
2010
119views more  BMCBI 2010»
13 years 5 months ago
Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study
Background: Gene silencing using exogenous small interfering RNAs (siRNAs) is now a widespread molecular tool for gene functional study and new-drug target identification. The key...
Qi Liu, Qian Xu, Vincent Wenchen Zheng, Hong Xue, ...
BMCBI
2010
167views more  BMCBI 2010»
13 years 5 months ago
Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies
Background: Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription fa...
Denitsa Alamanova, Philip Stegmaier, Alexander E. ...