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BMCBI
2010
100views more  BMCBI 2010»
13 years 5 months ago
Trimming of mammalian transcriptional networks using network component analysis
Background: Network Component Analysis (NCA) has been used to deduce the activities of transcription factors (TFs) from gene expression data and the TF-gene binding relationship. ...
Linh M. Tran, Daniel R. Hyduke, James C. Liao
BMCBI
2007
80views more  BMCBI 2007»
13 years 5 months ago
A network perspective on the topological importance of enzymes and their phylogenetic conservation
Background: A metabolic network is the sum of all chemical transformations or reactions in the cell, with the metabolites being interconnected by enzyme-catalyzed reactions. Many ...
Wei-chung Liu, Wen-hsien Lin, Andrew J. Davis, Fer...
BMCBI
2007
176views more  BMCBI 2007»
13 years 5 months ago
The Firegoose: two-way integration of diverse data from different bioinformatics web resources with desktop applications
Background: Information resources on the World Wide Web play an indispensable role in modern biology. But integrating data from multiple sources is often encumbered by the need to...
J. Christopher Bare, Paul T. Shannon, Amy K. Schmi...
BMCBI
2006
190views more  BMCBI 2006»
13 years 5 months ago
VANTED: A system for advanced data analysis and visualization in the context of biological networks
Background: Recent advances with high-throughput methods in life-science research have increased the need for automatized data analysis and visual exploration techniques. Sophisti...
Björn H. Junker, Christian Klukas, Falk Schre...
BMCBI
2006
104views more  BMCBI 2006»
13 years 5 months ago
MANET: tracing evolution of protein architecture in metabolic networks
Background: Cellular metabolism can be characterized by networks of enzymatic reactions and transport processes capable of supporting cellular life. Our aim is to find evolutionar...
Hee Shin Kim, Jay E. Mittenthal, Gustavo Caetano-A...