41 search results - page 1 / 9 » The functional importance of disease-associated mutation |
BMCBI
2002
13 years 4 months ago
2002
Background: For many years, scientists believed that point mutations in genes are the genetic switches for somatic and inherited diseases such as cystic fibrosis, phenylketonuria ...
BMCBI
2010
13 years 5 months ago
2010
Background: Mitochondrial DNA (mtDNA) is widely being used for population genetics, forensic DNA fingerprinting and clinical disease association studies. The recent past has uncov...
BMCBI
2007
13 years 5 months ago
2007
Background: A number of studies on biological networks have been carried out to unravel the topological characteristics that can explain the functional importance of network nodes...
BMCBI
2006
13 years 5 months ago
2006
Background: A number of methods that use both protein structural and evolutionary information are available to predict the functional consequences of missense mutations. However, ...
CEC
2009
IEEE
13 years 11 months ago
2009
IEEE
— Parameter setting is an important issue in the design of evolutionary algorithms. Recently, experimental work has pointed out that it is often not useful to work with a fixed ...