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» The meaning of alignment: lessons from structural diversity
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BMCBI
2008
109views more  BMCBI 2008»
13 years 4 months ago
The meaning of alignment: lessons from structural diversity
Background: Protein structural alignment provides a fundamental basis for deriving principles of functional and evolutionary relationships. It is routinely used for structural cla...
Walter Pirovano, K. Anton Feenstra, Jaap Heringa
MEDINFO
2007
139views Healthcare» more  MEDINFO 2007»
13 years 6 months ago
Lessons Learned from Cross-Validating Alignments between Large Anatomical Ontologies
Objectives: To compare the alignments of two large anatomical ontologies (the Foundational Model of Anatomy and GALEN) produced by three ontology alignment systems (AOAS, FALCON a...
Songmao Zhang, Olivier Bodenreider
ELPUB
2006
ACM
13 years 10 months ago
Living Reviews - Innovative Resources for Scholarly Communication Bridging Diverse Spheres of Disciplines and Organisational Str
This contribution presents the concept and analyses the path of diffusion of an innovative publishing idea that originated in one speciality in physics and is now about to spread ...
Claus Dalchow, Michael Nentwich, Patrick Scherhauf...
BMCBI
2006
143views more  BMCBI 2006»
13 years 4 months ago
Application of protein structure alignments to iterated hidden Markov model protocols for structure prediction
Background: One of the most powerful methods for the prediction of protein structure from sequence information alone is the iterative construction of profile-type models. Because ...
Eric D. Scheeff, Philip E. Bourne
BMCBI
2008
176views more  BMCBI 2008»
13 years 4 months ago
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Rainer Merkl, Matthias Zwick