We present multi-scale tracking features for the In Silico Liver (ISL) and their simulation results. The features were developed to support tracking of dynamic pharmacokinetic/pha...
Sunwoo Park, Sean H. J. Kim, Glen E. P. Ropella, C...
The In Silico Liver (ISL) plugs together autonomous software objects that represent hepatic components at different scales and levels of details. ISL parameters sensitive to drug-...
Li Yan, Sunwoo Park, Shahab Sheikh-Bahaei, Glen E....
Background: The number of protein targets with a known or predicted tri-dimensional structure and of drug-like chemical compounds is growing rapidly and so is the need for new the...
Nicolas Sauton, David Lagorce, Bruno O. Villoutrei...
Background: Optimization theory has been applied to complex biological systems to interrogate network properties and develop and refine metabolic engineering strategies. For examp...
Erwin P. Gianchandani, Matthew A. Oberhardt, Antho...