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» USPEX - Evolutionary crystal structure prediction
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BMCBI
2010
116views more  BMCBI 2010»
13 years 5 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
BMCBI
2010
105views more  BMCBI 2010»
13 years 5 months ago
Comparison of PGH2 binding site in prostaglandin synthases
Background: Prostaglandin H2 (PGH2) is a common precursor for the synthesis of five different Prostanoids via specific Prostanoid Synthases. The binding of this substrate with the...
Padmapriya Paragi-Vedanthi, Mukesh Doble
WCE
2007
13 years 6 months ago
High energy white beam x-ray diffraction studies of residual strains in engineering components
— In order to predict the durability of engineering components and improve performance, it is mandatory to understand residual stresses. The last decade has witnessed a significa...
Shu Yan Zhang, Willem J. J. Vorster, Tea-Sung Jun,...
BMCBI
2005
103views more  BMCBI 2005»
13 years 4 months ago
Many accurate small-discriminatory feature subsets exist in microarray transcript data: biomarker discovery
Background: Molecular profiling generates abundance measurements for thousands of gene transcripts in biological samples such as normal and tumor tissues (data points). Given such...
Leslie Grate