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BMCBI
2002
214views more  BMCBI 2002»
13 years 5 months ago
Automated modelling of signal transduction networks
Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ul...
Martin Steffen, Allegra Petti, John Aach, Patrik D...
IJON
2006
123views more  IJON 2006»
13 years 5 months ago
A novel approach to model neuronal signal transduction using stochastic differential equations
We introduce a new approach to model the behavior of neuronal signal transduction networks using stochastic differential equations. We present first a mathematical formulation for...
Tiina Manninen, Marja-Leena Linne, Keijo Ruohonen
BMCBI
2006
205views more  BMCBI 2006»
13 years 5 months ago
Application of Petri net based analysis techniques to signal transduction pathways
Background: Signal transduction pathways are usually modelled using classical quantitative methods, which are based on ordinary differential equations (ODEs). However, some diffic...
Andrea Sackmann, Monika Heiner, Ina Koch
BMCBI
2006
169views more  BMCBI 2006»
13 years 5 months ago
Beyond microarrays: Finding key transcription factors controlling signal transduction pathways
Background: Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cell...
Alexander E. Kel, Nico Voss, Ruy Jauregui, Olga V....
BIB
2008
93views more  BIB 2008»
13 years 5 months ago
A structured approach for the engineering of biochemical network models, illustrated for signalling pathways
Quantitative models of biochemical networks (signal transduction cascades, metabolic pathways, gene regulatory circuits) are a central component of modern systems biology. Buildin...
Rainer Breitling, David Gilbert, Monika Heiner, Ri...