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BMCBI
2010
145views more  BMCBI 2010»
13 years 23 days ago
Directionality in protein fold prediction
Background: Ever since the ground-breaking work of Anfinsen et al. in which a denatured protein was found to refold to its native state, it has been frequently stated by the prote...
Jonathan J. Ellis, Fabien P. E. Huard, Charlotte M...
BMCBI
2006
172views more  BMCBI 2006»
13 years 5 months ago
Prediction of cis/trans isomerization in proteins using PSI-BLAST profiles and secondary structure information
Background: The majority of peptide bonds in proteins are found to occur in the trans conformation. However, for proline residues, a considerable fraction of Prolyl peptide bonds ...
Jiangning Song, Kevin Burrage, Zheng Yuan, Thomas ...
BMCBI
2008
168views more  BMCBI 2008»
13 years 5 months ago
Predicting protein folding pathways at the mesoscopic level based on native interactions between secondary structure elements
Background: Since experimental determination of protein folding pathways remains difficult, computational techniques are often used to simulate protein folding. Most current techn...
Qingwu Yang, Sing-Hoi Sze
AE
2005
Springer
13 years 11 months ago
Incorporating Knowledge of Secondary Structures in a L-System-Based Encoding for Protein Folding
An encoding scheme for protein folding on lattice models, inspired by parametric L-systems, was proposed. The encoding incorporates problem domain knowledge in the form of predesig...
Gabriela Ochoa, Gabi Escuela, Natalio Krasnogor
BMCBI
2008
128views more  BMCBI 2008»
13 years 5 months ago
Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure
Background: Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models ...
Christopher Bystroff, Bobbie-Jo M. Webb-Robertson