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BMCBI
2007
107views more  BMCBI 2007»
13 years 5 months ago
Prediction of potential drug targets based on simple sequence properties
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
Qingliang Li, Luhua Lai
NAR
2011
199views Computer Vision» more  NAR 2011»
12 years 8 months ago
FragmentStore - a comprehensive database of fragments linking metabolites, toxic molecules and drugs
Consideration of biomolecules in terms of their molecular building blocks provides valuable new information regarding their synthesis, degradation and similarity. Here, we present...
Jessica Ahmed, Catherine L. Worth, Paul Florian Th...
BMCBI
2010
117views more  BMCBI 2010»
13 years 5 months ago
Extracting causal relations on HIV drug resistance from literature
Background: In HIV treatment it is critical to have up-to-date resistance data of applicable drugs since HIV has a very high rate of mutation. These data are made available throug...
Quoc-Chinh Bui, Breanndán Ó Nuall&aa...
BMCBI
2004
131views more  BMCBI 2004»
13 years 4 months ago
Detection of chromosomal regions showing differential gene expression in human skeletal muscle and in alveolar rhabdomyosarcoma
Background: Rhabdomyosarcoma is a relatively common tumour of the soft tissue, probably due to regulatory disruption of growth and differentiation of skeletal muscle stem cells. I...
Andrea Bisognin, Stefania Bortoluzzi, Gian Antonio...
BMCBI
2005
157views more  BMCBI 2005»
13 years 5 months ago
Decision Forest Analysis of 61 Single Nucleotide Polymorphisms in a Case-Control Study of Esophageal Cancer; a novel method
Background: Systematic evaluation and study of single nucleotide polymorphisms (SNPs) made possible by high throughput genotyping technologies and bioinformatics promises to provi...
Qian Xie, Luke D. Ratnasinghe, Huixiao Hong, Roger...