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BMCBI
2010
130views more  BMCBI 2010»
13 years 5 months ago
Amino acid "little Big Bang": Representing amino acid substitution matrices as dot products of Euclidian vectors
Background: Sequence comparisons make use of a one-letter representation for amino acids, the necessary quantitative information being supplied by the substitution matrices. This ...
Karel Zimmermann, Jean-François Gibrat
BMCBI
2010
146views more  BMCBI 2010»
13 years 5 months ago
Nonnegative principal component analysis for mass spectral serum profiles and biomarker discovery
Background: As a novel cancer diagnostic paradigm, mass spectroscopic serum proteomic pattern diagnostics was reported superior to the conventional serologic cancer biomarkers. Ho...
Henry Han
BMCBI
2008
100views more  BMCBI 2008»
13 years 5 months ago
PatternLab for proteomics: a tool for differential shotgun proteomics
Background: A goal of proteomics is to distinguish between states of a biological system by identifying protein expression differences. Liu et al. demonstrated a method to perform...
Paulo C. Carvalho, Juliana S. G. Fischer, Emily I....
ICML
2004
IEEE
14 years 6 months ago
Distribution kernels based on moments of counts
Many applications in text and speech processing require the analysis of distributions of variable-length sequences. We recently introduced a general kernel framework, rational ker...
Corinna Cortes, Mehryar Mohri
BIODATAMINING
2008
163views more  BIODATAMINING 2008»
13 years 5 months ago
Multivariate profiling of neurodegeneration-associated changes in a subcellular compartment of neurons via image processing
Background: Dysfunction in the endolysosome, a late endosomal to lysosomal degradative intracellular compartment, is an early hallmark of some neurodegenerative diseases, in parti...
Saravana K. Kumarasamy, Yunshi Wang, Vignesh Viswa...