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BMCBI
2006
123views more  BMCBI 2006»
13 years 4 months ago
Computational models with thermodynamic and composition features improve siRNA design
Background: Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large fun...
Svetlana A. Shabalina, Alexey N. Spiridonov, Aleks...
IJCNN
2007
IEEE
13 years 11 months ago
Agnostic Learning versus Prior Knowledge in the Design of Kernel Machines
Abstract— The optimal model parameters of a kernel machine are typically given by the solution of a convex optimisation problem with a single global optimum. Obtaining the best p...
Gavin C. Cawley, Nicola L. C. Talbot
BMCBI
2008
220views more  BMCBI 2008»
13 years 4 months ago
Gene prediction in metagenomic fragments: A large scale machine learning approach
Background: Metagenomics is an approach to the characterization of microbial genomes via the direct isolation of genomic sequences from the environment without prior cultivation. ...
Katharina J. Hoff, Maike Tech, Thomas Lingner, Rol...