Background: Insertions and deletions (indels) represent a common type of sequence variations, which are less studied and pose many important biological questions. Recent research ...
Background: The recent explosion in the availability of complete genome sequences has led to the cataloging of tens of thousands of new proteins and putative proteins. Many of the...
NCBI’s Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from...
Aron Marchler-Bauer, Shennan Lu, John B. Anderson,...
Background: Many protein families have undergone functional divergence after gene duplications such that current subgroups of the family carry out overlapping but distinct biologi...
Xiang Gao, Kent Vander Velden, Daniel F. Voytas, X...
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...