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CMSB
2009
Springer
13 years 11 months ago
The Equivalence between Biology and Computation
A major challenge in computational systems biology is the articulation of a biological process in a form which can be understood by the biologist yet is amenable to computational e...
John K. Heath
CMSB
2009
Springer
13 years 11 months ago
Probabilistic Approximations of Signaling Pathway Dynamics
Systems of ordinary differential equations (ODEs) are often used to model the dynamics of complex biological pathways. We construct a discrete state model as a probabilistic appro...
Bing Liu, P. S. Thiagarajan, David Hsu
CMSB
2009
Springer
13 years 11 months ago
Approximation of Event Probabilities in Noisy Cellular Processes
Molecular noise, which arises from the randomness of the discrete events in the cell, significantly influences fundamental biological processes. Discrete-state continuous-time st...
Frédéric Didier, Thomas A. Henzinger...
CMSB
2009
Springer
13 years 8 months ago
On Coupling Models Using Model-Checking: Effects of Irinotecan Injections on the Mammalian Cell Cycle
Abstract. In systems biology, the number of models of cellular processes increases rapidly, but re-using models in different contexts or for different questions remains a challengi...
Elisabetta De Maria, François Fages, Sylvai...
CMSB
2009
Springer
13 years 11 months ago
Modelling Biological Clocks with Bio-PEPA: Stochasticity and Robustness for the Neurospora crassa Circadian Network
Circadian clocks are biochemical networks, present in nearly all living organisms, whose function is to regulate the expression of specific mRNAs and proteins to synchronise rhyth...
Ozgur E. Akman, Federica Ciocchetta, Andrea Degasp...