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JCB
2000
107views more  JCB 2000»
13 years 5 months ago
A Discriminative Framework for Detecting Remote Protein Homologies
A new method for detecting remote protein homologies is introduced and shown to perform well in classifying protein domains by SCOP superfamily. The method is a variant of support...
Tommi Jaakkola, Mark Diekhans, David Haussler
JCB
2000
91views more  JCB 2000»
13 years 5 months ago
Scaling Laws and Similarity Detection in Sequence Alignment with Gaps
We study the problem of similarity detection by sequence alignment with gaps, using a recently established theoretical framework based on the morphology of alignment paths. Alignm...
Dirk Drasdo, Terence Hwa, Michael Lässig
JCB
2000
105views more  JCB 2000»
13 years 5 months ago
A Greedy Algorithm for Aligning DNA Sequences
For aligning DNA sequences that differ only by sequencing errors, or by equivalent errors from other sources, a greedy algorithm can be much faster than traditional dynamic progra...
Zheng Zhang 0004, Scott Schwartz, Lukas Wagner, We...
JCB
2000
87views more  JCB 2000»
13 years 5 months ago
Comparison of Additive Trees Using Circular Orders
It has been postulated that existing species have been linked in the past in a way that can be described using an additive tree structure. Any such tree structure reflecting speci...
Vladimir Makarenkov, Bruno Leclerc
JCB
2000
137views more  JCB 2000»
13 years 5 months ago
NOTUNG: A Program for Dating Gene Duplications and Optimizing Gene Family Trees
Large scale gene duplication is a major force driving the evolution of genetic functional innovation. Whole genome duplications are widely believed to have played an important rol...
Kevin Chen, Dannie Durand, Martin Farach-Colton