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JCB
2006
115views more  JCB 2006»
13 years 6 months ago
Designing an A* Algorithm for Calculating Edit Distance between Rooted-Unordered Trees
Tree structures are useful for describing and analyzing biological objects and processes. Consequently, there is a need to design metrics and algorithms to compare trees. A natura...
Yair Horesh, Ramit Mehr, Ron Unger
JCB
2006
129views more  JCB 2006»
13 years 6 months ago
GenRate: A Generative Model that Reveals Novel Transcripts in Genome-Tiling Microarray Data
Genome-wide microarray designs containing millions to hundreds of millions of probes are available for a variety of mammals, including mouse and human. These genome tiling arrays ...
Brendan J. Frey, Quaid Morris, Timothy R. Hughes
JCB
2006
123views more  JCB 2006»
13 years 6 months ago
Reconstructing Ancestral Haplotypes with a Dictionary Model
We propose a dictionary model for haplotypes. According to the model, a haplotype is constructed by randomly concatenating haplotype segments from a given dictionary of segments. ...
Kristin L. Ayers, Chiara Sabatti, Kenneth Lange
JCB
2006
185views more  JCB 2006»
13 years 6 months ago
A Probabilistic Methodology for Integrating Knowledge and Experiments on Biological Networks
Biological systems are traditionally studied by focusing on a specific subsystem, building an intuitive model for it, and refining the model using results from carefully designed ...
Irit Gat-Viks, Amos Tanay, Daniela Raijman, Ron Sh...
JCB
2006
144views more  JCB 2006»
13 years 6 months ago
Modeling Virus Self-Assembly Pathways: Avoiding Dynamics Using Geometric Constraint Decomposition
We develop a model for elucidating the assembly pathways by which an icosahedral viral shell forms from 60 identical constituent protein monomers. This poorly understood process a...
Meera Sitharam, Mavis Agbandje-Mckenna