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JCB
2007
94views more  JCB 2007»
13 years 5 months ago
A Quantile Method for Sizing Optical Maps
Optical mapping is an integrated system for the analysis of single DNA molecules. It constructs restriction maps (noted as “optical map”) from individual DNA molecules present...
Haifeng Li, Anton Valouev, David C. Schwartz, Mich...
JCB
2007
118views more  JCB 2007»
13 years 5 months ago
Discovering Topological Motifs Using a Compact Notation
Discovering topological motifs or common topologies in one or more graphs is an important as well as an interesting problem. It had been classically viewed as the subgraph isomorp...
Laxmi Parida
JCB
2007
198views more  JCB 2007»
13 years 5 months ago
Bayesian Hierarchical Model for Large-Scale Covariance Matrix Estimation
Many bioinformatics problems can implicitly depend on estimating large-scale covariance matrix. The traditional approaches tend to give rise to high variance and low accuracy esti...
Dongxiao Zhu, Alfred O. Hero III
JCB
2007
144views more  JCB 2007»
13 years 5 months ago
Statistical Estimation of Statistical Mechanical Models: Helix-Coil Theory and Peptide Helicity Prediction
Analysis of biopolymer sequences and structures generally adopts one of two approaches: use of detailed biophysical theoretical models of the system with experimentally-determined...
Scott C. Schmidler, Joseph E. Lucas, Terrence G. O...
JCB
2007
145views more  JCB 2007»
13 years 5 months ago
Confounding Factors in HGT Detection: Statistical Error, Coalescent Effects, and Multiple Solutions
Prokaryotic organisms share genetic material across species boundaries by means of a process known as horizontal gene transfer (HGT). This process has great significance for unde...
Cuong Than, Derek A. Ruths, Hideki Innan, Luay Nak...