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» rnaDesign: Local search for RNA secondary structure design
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CIBCB
2009
IEEE
9 years 8 months ago
rnaDesign: Local search for RNA secondary structure design
Abstract-- The RNA secondary structure design (SSD) problem is a recently emerging research topic motivated by applications such as customized drug design and the self-assembly of ...
Denny C. Dai, Herbert H. Tsang, Kay C. Wiese
BIBM
2008
IEEE
105views Bioinformatics» more  BIBM 2008»
10 years 1 months ago
Energy Profile and Secondary Structure Impact shRNA Efficacy
Many characteristics of functional synthetic siRNAs have been identified. Our three-phase algorithm was developed to design siRNA on a wholegenome scale based on these characteris...
Hong Zhou, Xiao Zeng
BIBE
2007
IEEE
138views Bioinformatics» more  BIBE 2007»
10 years 1 months ago
A Flexible Stem-Based Local Search Algorithm for Predicting RNA Secondary Structures Including Pseudoknots
-We demonstrate a new algorithm named FlexStem to predict RNA secondary structures with pseudoknots. Our approach is based on the free energy minimization criterion, and utilizes a...
Xiang Chen, Simin He, Dongbo Bu, Runsheng Chen, We...
BMCBI
2005
306views more  BMCBI 2005»
9 years 7 months ago
A method for aligning RNA secondary structures and its application to RNA motif detection
Background: Alignment of RNA secondary structures is important in studying functional RNA motifs. In recent years, much progress has been made in RNA motif finding and structure a...
Jianghui Liu, Jason Tsong-Li Wang, Jun Hu, Bin Tia...
GCB
2010
Springer
198views Biometrics» more  GCB 2010»
9 years 5 months ago
RNALfoldz: Efficient Prediction of Thermodynamically Stable, Local Secondary Structures
Abstract: The search for local RNA secondary structures and the annotation of unusually stable folding regions in genomic sequences are two well motivated bioinformatic problems. I...
Andreas R. Gruber, Stephan H. F. Bernhart, You Zho...
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