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BMCBI
2008
90views more  BMCBI 2008»
13 years 5 months ago
Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation
Background: The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent res...
Jakub Orzechowski Westholm, Feifei Xu, Hans Ronne,...
BMCBI
2008
83views more  BMCBI 2008»
13 years 5 months ago
Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells
Background: Microarray technology has unveiled transcriptomic differences among tumors of various phenotypes, and, especially, brought great progress in molecular understanding of...
Atsushi Niida, Andrew D. Smith, Seiya Imoto, Shuic...
BMCBI
2008
126views more  BMCBI 2008»
13 years 5 months ago
c-REDUCE: Incorporating sequence conservation to detect motifs that correlate with expression
Background: Computational methods for characterizing novel transcription factor binding sites search for sequence patterns or "motifs" that appear repeatedly in genomic ...
Katerina Kechris, Hao Li
DM
1998
91views more  DM 1998»
13 years 4 months ago
On some relations between 2-trees and tree metrics
A tree function (TF) t on a ÿnite set X is a real function on the set of the pairs of elements of X satisfying the four-point condition: for all distinct x; y; z; w ∈ X; t(xy)+...
Bruno Leclerc, Vladimir Makarenkov