BMCBI
2010
13 years 2 months ago
2010
Background: Mass spectrometry has become a standard method by which the proteomic profile of cell or tissue samples is characterized. To fully take advantage of tandem mass spectr...
BMCBI
2010
13 years 2 months ago
2010
Background: External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gen...
BMCBI
2010
13 years 2 months ago
2010
Background: To exploit the flood of data from advances in high throughput imaging of optically sectioned nuclei, image analysis methods need to correctly detect thousands of nucle...
BMCBI
2010
13 years 2 months ago
2010
Background: The purpose of this manuscript is to provide, based on an extensive analysis of a proteomic data set, suggestions for proper statistical analysis for the discovery of ...
BMCBI
2010
13 years 2 months ago
2010
Background: Recent studies have revealed the importance of considering the entire distribution of possible secondary structures in RNA secondary structure predictions; therefore, ...
BMCBI
2010
13 years 2 months ago
2010
BMCBI
2010
13 years 2 months ago
2010
Background: Traditional genome alignment methods consider sequence alignment as a variation of the string edit distance problem, and perform alignment by matching characters of th...
BMCBI
2010
13 years 2 months ago
2010
Background: Models for the simulation of metabolic networks require the accurate prediction of enzyme function. Based on a genomic sequence, enzymatic functions of gene products a...
BMCBI
2010
13 years 2 months ago
2010
Background: The preprocessing of gene expression data obtained from several platforms routinely includes the aggregation of multiple raw signal intensities to one expression value...
BMCBI
2010
13 years 2 months ago
2010
Background: Expression levels for 47294 transcripts in lymphoblastoid cell lines from all 270 HapMap phase II individuals, and genotypes (both HapMap phase II and III) of 3.96 mil...