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RECOMB
2008
Springer
9 years 6 months ago
Duplication Mechanism and Disruptions in Flanking Regions Influence the Fate of Mammalian Gene Duplicates
Here we identify duplicated genes in five mammalian genomes and classify these duplicates based on the mechanisms by which they were generated. Retrotransposition accounts for at l...
Paul Ryvkin, Jin Jun, Edward Hemphill, Craig Nelso...
RECOMB
2008
Springer
9 years 6 months ago
Automatic Recognition of Cells (ARC) for 3D Images of C. elegans
The development of high-resolution microscopy makes possible the high-throughput screening of cellular information, such as gene expression at single cell resolution. One of the cr...
Fuhui Long, Hanchuan Peng, Xiao Liu, Stuart K. Kim...
RECOMB
2008
Springer
9 years 6 months ago
Automatic Parameter Learning for Multiple Network Alignment
We developed Gr?mlin 2.0, a new multiple network aligner with (1) a novel scoring function that can use arbitrary features of a multiple network alignment, such as protein deletion...
Jason Flannick, Antal F. Novak, Chuong B. Do, Bala...
RECOMB
2008
Springer
9 years 6 months ago
DLIGHT - Lateral Gene Transfer Detection Using Pairwise Evolutionary Distances in a Statistical Framework
Abstract. This paper presents an algorithm to detect lateral gene transfer (LGT) on the basis of pairwise evolutionary distances. The prediction is made from a likelihood ratio der...
Christophe Dessimoz, Daniel Margadant, Gaston H. G...
RECOMB
2008
Springer
9 years 6 months ago
Accurate Computation of Likelihoods in the Coalescent with Recombination Via Parsimony
Understanding the variation of recombination rates across a given genome is crucial for disease gene mapping and for detecting signatures of selection, to name just a couple of app...
Jotun Hein, Rune B. Lyngsø, Yun S. Song
RECOMB
2008
Springer
9 years 6 months ago
De Novo Sequencing of Nonribosomal Peptides
Abstract. While nonribosomal peptides (NRPs) are of tremendous pharmacological importance, there is currently no technology capable of highthroughput sequencing of NRPs. Difficulti...
Nuno Bandeira, Julio Ng, Dario Meluzzi, Roger G. L...
RECOMB
2008
Springer
9 years 6 months ago
Spectrum Fusion: Using Multiple Mass Spectra for De Novo Peptide Sequencing
We report on a new algorithm for combining the information from several mass spectra of the same peptide. The algorithm automatically learns peptide fragmentation patterns, so that...
Ritendra Datta, Marshall W. Bern
RECOMB
2008
Springer
9 years 6 months ago
A Bayesian Approach to Protein Inference Problem in Shotgun Proteomics
The protein inference problem represents a major challenge in shotgun proteomics. Here we describe a novel Bayesian approach to address this challenge that incorporates the predict...
Yong Fuga Li, Randy J. Arnold, Yixue Li, Predrag R...
RECOMB
2008
Springer
9 years 6 months ago
Bootstrapping the Interactome: Unsupervised Identification of Protein Complexes in Yeast
Protein interactions and complexes are major components of biological systems. Recent genome-wide applications of tandem affinity purification (TAP) in yeast have increased signifi...
Caroline C. Friedel, Jan Krumsiek, Ralf Zimmer
RECOMB
2008
Springer
9 years 6 months ago
Fast and Accurate Alignment of Multiple Protein Networks
Comparative analysis of protein networks has proven to be a powerful approach for elucidating network structure and predicting protein function and interaction. A fundamental chall...
Maxim Kalaev, Vineet Bafna, Roded Sharan
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