NAR
2007
13 years 4 months ago
2007
Understanding interactions between proteins and RNA is key to deciphering the mechanisms of many important biological processes. Here we describe RNABindR, a web-based server that...
CORR
2002
Springer
13 years 4 months ago
2002
Springer
It is widely accepted that (1) the natural or folded state of proteins is a global energy minimum, and (2) in most cases proteins fold to a unique state determined by their amino ...
BMCBI
2004
13 years 4 months ago
2004
Background: Existing sequence alignment algorithms assume that similarities between DNA or amino acid sequences are linearly ordered. That is, stretches of similar nucleotides or ...
BMCBI
2004
13 years 4 months ago
2004
Background: There are two different theories about the development of the genetic code. Woese suggested that it was developed in connection with the amino acid repertoire, while C...
JCC
2007
13 years 4 months ago
2007
: It has tremendous values for both drug discovery and basic research to develop a solid bioinformatical tool for guiding peptide reagent design. Based on the physical and chemical...
BMCBI
2005
13 years 4 months ago
2005
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
BMCBI
2005
13 years 4 months ago
2005
Background: General protein evolution models help determine the baseline expectations for the evolution of sequences, and they have been extensively useful in sequence analysis an...
BMCBI
2005
13 years 4 months ago
2005
Background: The chemical property and biological function of a protein is a direct consequence of its primary structure. Several algorithms have been developed which determine ali...
BMCBI
2005
13 years 4 months ago
2005
Background: Beta-barrel transmembrane (bbtm) proteins are a functionally important and diverse group of proteins expressed in the outer membranes of bacteria (both gram negative a...
BMCBI
2005
13 years 4 months ago
2005
Background: Single amino acid repeats make up a significant proportion in all of the proteomes that have currently been determined. They have been shown to be functionally and med...