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BIB
2010
103views more  BIB 2010»
11 years 5 months ago
Challenges of sequencing human genomes
Massively parallel sequencing technologies continue to alter the study of human genetics. As the cost of sequencing declines, next-generation sequencing (NGS) instruments and data...
Daniel C. Koboldt, Li Ding, Elaine R. Mardis, Rich...
BIB
2010
140views more  BIB 2010»
11 years 5 months ago
Next generation sequencing in functional genomics
Genome-wide sequencing has enabled modern biomedical research to relate more and more events in healthy as well as disease-affected cells and tissues to the genomic sequence. Now ...
Thomas Werner
BIB
2010
89views more  BIB 2010»
11 years 7 months ago
Knowledge-based data analysis comes of age
The emergence of high-throughput technologies for measuring biological systems has introduced problems for data interpretation that must be addressed for proper inference. First, ...
Michael F. Ochs
BIB
2010
129views more  BIB 2010»
11 years 8 months ago
Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology
PathwayTools is a production-quality software environment for creating a type of model-organism database called a Pathway/Genome Database (PGDB). A PGDB such as EcoCyc integrates ...
Peter D. Karp, Suzanne M. Paley, Markus Krummenack...
BIB
2010
68views more  BIB 2010»
11 years 8 months ago
Genome variation discovery with high-throughput sequencing data
The advent of high-throughput sequencing (HTS) technologies is enabling sequencing of human genomes at a significantly lower cost. The availability of these genomes is hoped to en...
Adrian V. Dalca, Michael Brudno
BIB
2010
147views more  BIB 2010»
11 years 8 months ago
Toward the dynamic interactome: it's about time
Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms.The availability of experimentally determined large-scale cellular networks...
Teresa M. Przytycka, Mona Singh, Donna K. Slonim
BIB
2010
79views more  BIB 2010»
11 years 8 months ago
Simulation of P systems with active membranes on CUDA
José M. Cecilia, José M. Garcí...
BIB
2010
131views more  BIB 2010»
11 years 8 months ago
Multi-scale modelling in computational biomedicine
The inherent complexity of biomedical systems is well recognized; they are multi-scale, multi-science systems, bridging a wide range of temporal and spatial scales. This article r...
Peter M. A. Sloot, Alfons G. Hoekstra
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