BMCBI
2010
13 years 4 months ago
2010
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
BMCBI
2010
13 years 4 months ago
2010
Background: MHC/HLA class II molecules are important components of the immune system and play a critical role in processes such as phagocytosis. Understanding peptide recognition ...
BMCBI
2010
13 years 4 months ago
2010
Background: Chromatin immunoprecipitation (ChIP) followed by high-throughput sequencing (ChIP-seq) or ChIP followed by genome tiling array analysis (ChIP-chip) have become standar...
BMCBI
2010
13 years 4 months ago
2010
Background: One of the challenges of bioinformatics remains the recognition of short signal sequences in genomic DNA such as donor or acceptor splice sites, splicing enhancers or ...
BMCBI
2010
13 years 4 months ago
2010
Background: The recognition of functional binding sites in genomic DNA remains one of the fundamental challenges of genome research. During the last decades, a plethora of differe...
BMCBI
2010
13 years 4 months ago
2010
Background: ChIP-Seq, which combines chromatin immunoprecipitation (ChIP) with high-throughput massively parallel sequencing, is increasingly being used for identification of prot...
APBC
2008
13 years 6 months ago
2008
: Finding motifs and the corresponding binding sites is a critical and challenging problem in studying the process of gene expression. String and matrix representations are two pop...
AOSD
2008
ACM
13 years 6 months ago
2008
ACM
In a software product line, the binding time of a feature is the time at which one decides to include or exclude a feature from a product. Typical binding site implementations are...
CSB
2003
IEEE
13 years 9 months ago
2003
IEEE
Regulatory sequence elements provide important clues to understanding and predicting gene expression. Although the binding sites for hundreds of transcription factors are known, t...
WABI
2009
Springer
13 years 11 months ago
2009
Springer
We present biRNA, a novel algorithm for prediction of binding sites between two RNAs based on minimization of binding free energy. Similar to RNAup approach [30], we assume the bin...