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BMCBI
2002
126views more  BMCBI 2002»
11 years 6 months ago
RIO: Analyzing proteomes by automated phylogenomics using resampled inference of orthologs
Background: When analyzing protein sequences using sequence similarity searches, orthologous sequences (that diverged by speciation) are more reliable predictors of a new protein&...
Christian M. Zmasek, Sean R. Eddy
BMCBI
2002
101views more  BMCBI 2002»
11 years 6 months ago
Match-Only Integral Distribution (MOID) Algorithm for high-density oligonucleotide array analysis
Background: High-density oligonucleotide arrays have become a valuable tool for highthroughput gene expression profiling. Increasing the array information density and improving th...
Yingyao Zhou, Ruben Abagyan
BMCBI
2002
134views more  BMCBI 2002»
11 years 6 months ago
CoreGenes: A computational tool for identifying and cataloging "core" genes in a set of small genomes
Background: Improvements in DNA sequencing technology and methodology have led to the rapid expansion of databases comprising DNA sequence, gene and genome data. Lower operational...
Nikhat Zafar, Raja Mazumder, Donald Seto
BMCBI
2002
94views more  BMCBI 2002»
11 years 6 months ago
Computational method for reducing variance with Affymetrix microarrays
Background: Affymetrix microarrays are used by many laboratories to generate gene expression
Stephen Welle, Andrew I. Brooks, Charles A. Thornt...
BMCBI
2002
195views more  BMCBI 2002»
11 years 6 months ago
Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study
Background: A method to evaluate and analyze the massive data generated by series of microarray experiments is of utmost importance to reveal the hidden patterns of gene expressio...
Junbai Wang, Jan Delabie, Hans Christian Aasheim, ...
BMCBI
2002
133views more  BMCBI 2002»
11 years 6 months ago
Identification and characterization of subfamily-specific signatures in a large protein superfamily by a hidden Markov model app
Background: Most profile and motif databases strive to classify protein sequences into a broad spectrum of protein families. The next step of such database studies should include ...
Kevin Truong, Mitsuhiko Ikura
BMCBI
2002
110views more  BMCBI 2002»
11 years 6 months ago
Identifying functional relationships among human genes by systematic analysis of biological literature
Background: The availability of biomedical literature in electronic format has made it possible to implement automatic text processing methods to expose implicit relationships amo...
Yong-Chuan Tao, Rudolph L. Leibel
BMCBI
2002
214views more  BMCBI 2002»
11 years 6 months ago
Automated modelling of signal transduction networks
Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ul...
Martin Steffen, Allegra Petti, John Aach, Patrik D...
BMCBI
2002
131views more  BMCBI 2002»
11 years 6 months ago
Efficient Boolean implementation of universal sequence maps (bUSM)
Background: Recently, Almeida and Vinga offered a new approach for the representation of arbitrary discrete sequences, referred to as Universal Sequence Maps (USM), and discussed ...
John Schwacke, Jonas S. Almeida
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