BMCBI
2002
13 years 4 months ago
2002
Background: When analyzing protein sequences using sequence similarity searches, orthologous sequences (that diverged by speciation) are more reliable predictors of a new protein&...
BMCBI
2002
13 years 4 months ago
2002
Background: High-density oligonucleotide arrays have become a valuable tool for highthroughput gene expression profiling. Increasing the array information density and improving th...
BMCBI
2002
13 years 4 months ago
2002
Background: Improvements in DNA sequencing technology and methodology have led to the rapid expansion of databases comprising DNA sequence, gene and genome data. Lower operational...
BMCBI
2002
13 years 4 months ago
2002
Background: Affymetrix microarrays are used by many laboratories to generate gene expression
BMCBI
2002
13 years 4 months ago
2002
Background: A method to evaluate and analyze the massive data generated by series of microarray experiments is of utmost importance to reveal the hidden patterns of gene expressio...
BMCBI
2002
13 years 4 months ago
2002
Background: Most profile and motif databases strive to classify protein sequences into a broad spectrum of protein families. The next step of such database studies should include ...
BMCBI
2002
13 years 4 months ago
2002
Background: The availability of biomedical literature in electronic format has made it possible to implement automatic text processing methods to expose implicit relationships amo...
BMCBI
2002
13 years 4 months ago
2002
Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ul...
BMCBI
2002
13 years 4 months ago
2002
Background: Recently, Almeida and Vinga offered a new approach for the representation of arbitrary discrete sequences, referred to as Universal Sequence Maps (USM), and discussed ...