BMCBI
2004
13 years 4 months ago
2004
Background: The genomes of an increasing number of species are being investigated through generation of expressed sequence tags (ESTs). However, ESTs are prone to sequencing error...
BMCBI
2004
13 years 4 months ago
2004
Background: An important challenge for transcript counting methods such as Serial Analysis of Gene Expression (SAGE), "Digital Northern" or Massively Parallel Signature ...
BMCBI
2004
13 years 4 months ago
2004
Background: To identify differentially expressed genes, it is standard practice to test a twosample hypothesis for each gene with a proper adjustment for multiple testing. Such te...
BMCBI
2004
13 years 4 months ago
2004
Background: The behaviors of cells in metazoans are context dependent, thus large-scale multicellular modeling is often necessary, for which cellular automata are natural candidat...
BMCBI
2004
13 years 4 months ago
2004
Background: Once specific genes are identified through high throughput genomics technologies there is a need to sort the final gene list to a manageable size for validation studie...
BMCBI
2004
13 years 4 months ago
2004
Background: Identifying all protein-protein interactions in an organism is a major objective of proteomics. A related goal is to know which protein pairs are present in the same p...
BMCBI
2004
13 years 4 months ago
2004
Background: In population-based studies, it is generally recognized that single nucleotide polymorphism (SNP) markers are not independent. Rather, they are carried by haplotypes, ...
BMCBI
2004
13 years 4 months ago
2004
Background: Microarray and other high-throughput technologies are producing large sets of interesting genes that are difficult to analyze directly. Bioinformatics tools are needed...
BMCBI
2004
13 years 4 months ago
2004
Background: In the microarray experiment, many undesirable systematic variations are commonly observed. Normalization is the process of removing such variation that affects the me...
BMCBI
2004
13 years 4 months ago
2004
Background: cDNA microarrays are a powerful means to screen for biologically relevant gene expression changes, but are often limited by their ability to detect small changes accur...