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BMCBI
2004
87views more  BMCBI 2004»
8 years 5 months ago
prot4EST: Translating Expressed Sequence Tags from neglected genomes
Background: The genomes of an increasing number of species are being investigated through generation of expressed sequence tags (ESTs). However, ESTs are prone to sequencing error...
James Wasmuth, Mark L. Blaxter
BMCBI
2004
134views more  BMCBI 2004»
8 years 5 months ago
Bayesian model accounting for within-class biological variability in Serial Analysis of Gene Expression (SAGE)
Background: An important challenge for transcript counting methods such as Serial Analysis of Gene Expression (SAGE), "Digital Northern" or Massively Parallel Signature ...
Ricardo Z. N. Vêncio, Helena Brentani, Diogo...
BMCBI
2004
146views more  BMCBI 2004»
8 years 5 months ago
Multivariate search for differentially expressed gene combinations
Background: To identify differentially expressed genes, it is standard practice to test a twosample hypothesis for each gene with a proper adjustment for multiple testing. Such te...
Yuanhui Xiao, Robert D. Frisina, Alexander Gordon,...
BMCBI
2004
121views more  BMCBI 2004»
8 years 5 months ago
Asynchronous adaptive time step in quantitative cellular automata modeling
Background: The behaviors of cells in metazoans are context dependent, thus large-scale multicellular modeling is often necessary, for which cellular automata are natural candidat...
Hao Zhu, Peter Y. H. Pang, Yan Sun, Pawan Dhar
BMCBI
2004
189views more  BMCBI 2004»
8 years 5 months ago
B.E.A.R. GeneInfo: A tool for identifying gene-related biomedical publications through user modifiable queries
Background: Once specific genes are identified through high throughput genomics technologies there is a need to sort the final gene list to a manageable size for validation studie...
Guohui Zhou, Xinyu Wen, Hang Liu, Michael J. Schli...
BMCBI
2004
112views more  BMCBI 2004»
8 years 5 months ago
Predicting co-complexed protein pairs using genomic and proteomic data integration
Background: Identifying all protein-protein interactions in an organism is a major objective of proteomics. A related goal is to know which protein pairs are present in the same p...
Lan V. Zhang, Sharyl L. Wong, Oliver D. King, Fred...
BMCBI
2004
112views more  BMCBI 2004»
8 years 5 months ago
A double classification tree search algorithm for index SNP selection
Background: In population-based studies, it is generally recognized that single nucleotide polymorphism (SNP) markers are not independent. Rather, they are carried by haplotypes, ...
Peisen Zhang, Huitao Sheng, Ryuhei Uehara
BMCBI
2004
142views more  BMCBI 2004»
8 years 5 months ago
GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies
Background: Microarray and other high-throughput technologies are producing large sets of interesting genes that are difficult to analyze directly. Bioinformatics tools are needed...
Bing Zhang, Denise Schmoyer, Stefan Kirov, Jay Sno...
BMCBI
2004
132views more  BMCBI 2004»
8 years 5 months ago
Two-stage normalization using background intensities in cDNA microarray data
Background: In the microarray experiment, many undesirable systematic variations are commonly observed. Normalization is the process of removing such variation that affects the me...
Dankyu Yoon, Sung-Gon Yi, Ju-Han Kim, Taesung Park
BMCBI
2004
154views more  BMCBI 2004»
8 years 5 months ago
Accuracy of cDNA microarray methods to detect small gene expression changes induced by neuregulin on breast epithelial cells
Background: cDNA microarrays are a powerful means to screen for biologically relevant gene expression changes, but are often limited by their ability to detect small changes accur...
Bin Yao, Sanjay N. Rakhade, Qunfang Li, Sharlin Ah...
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