BMCBI
2004
13 years 4 months ago
2004
Background: It is a major challenge of computational biology to provide a comprehensive functional classification of all known proteins. Most existing methods seek recurrent patte...
BMCBI
2004
13 years 4 months ago
2004
Background: Multi-locus sequence typing (MLST) is a method of typing that facilitates the discrimination of microbial isolates by comparing the sequences of housekeeping gene frag...
BMCBI
2004
13 years 4 months ago
2004
Background: Due to the high cost and low reproducibility of many microarray experiments, it is not surprising to find a limited number of patient samples in each study, and very f...
BMCBI
2004
13 years 4 months ago
2004
Background: Recently, mass spectrometry data have been mined using a genetic algorithm to produce discriminatory models that distinguish healthy individuals from those with cancer...
BMCBI
2004
13 years 4 months ago
2004
Background: One of the important challenges in microarray analysis is to take full advantage of previously accumulated data, both from one's own laboratory and from public re...
BMCBI
2004
13 years 4 months ago
2004
Background: Common existing phylogenetic tree visualisation tools are not able to display readable trees with more than a few thousand nodes. These existing methodologies are base...
BMCBI
2004
13 years 4 months ago
2004
Background: SNP genotyping typically incorporates a review step to ensure that the genotype calls for a particular SNP are correct. For high-throughput genotyping, such as that pr...
BMCBI
2004
13 years 4 months ago
2004
Background: Detailed knowledge of the subcellular location of each expressed protein is critical to a full understanding of its function. Fluorescence microscopy, in combination w...
BMCBI
2004
13 years 4 months ago
2004
Background: Regulatory regions that function in DNA replication and gene transcription contain specific sequences that bind proteins as well as less-specific sequences in which th...