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BMCBI
2004
125views more  BMCBI 2004»
8 years 11 months ago
A functional hierarchical organization of the protein sequence space
Background: It is a major challenge of computational biology to provide a comprehensive functional classification of all known proteins. Most existing methods seek recurrent patte...
Noam Kaplan, Moriah Friedlich, Menachem Fromer, Mi...
BMCBI
2004
139views more  BMCBI 2004»
8 years 11 months ago
mlstdbNet - distributed multi-locus sequence typing (MLST) databases
Background: Multi-locus sequence typing (MLST) is a method of typing that facilitates the discrimination of microbial isolates by comparing the sequences of housekeeping gene frag...
Keith A. Jolley, Man-Suen Chan, Martin C. J. Maide...
BMCBI
2004
75views more  BMCBI 2004»
8 years 11 months ago
Joint analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker genes
Background: Due to the high cost and low reproducibility of many microarray experiments, it is not surprising to find a limited number of patient samples in each study, and very f...
Hongying Jiang, Youping Deng, Huann-Sheng Chen, Li...
BMCBI
2004
97views more  BMCBI 2004»
8 years 11 months ago
Performance of a genetic algorithm for mass spectrometry proteomics
Background: Recently, mass spectrometry data have been mined using a genetic algorithm to produce discriminatory models that distinguish healthy individuals from those with cancer...
Neal O. Jeffries
BMCBI
2004
206views more  BMCBI 2004»
8 years 11 months ago
Combining gene expression data from different generations of oligonucleotide arrays
Background: One of the important challenges in microarray analysis is to take full advantage of previously accumulated data, both from one's own laboratory and from public re...
Kyu Baek Hwang, Sek Won Kong, Steven A. Greenberg,...
BMCBI
2004
126views more  BMCBI 2004»
8 years 11 months ago
Visualising very large phylogenetic trees in three dimensional hyperbolic space
Background: Common existing phylogenetic tree visualisation tools are not able to display readable trees with more than a few thousand nodes. These existing methodologies are base...
Timothy Hughes, Young Hyun, David A. Liberles
BMCBI
2004
100views more  BMCBI 2004»
8 years 11 months ago
Auto-validation of fluorescent primer extension genotyping assay using signal clustering and neural networks
Background: SNP genotyping typically incorporates a review step to ensure that the genotype calls for a particular SNP are correct. For high-throughput genotyping, such as that pr...
Ching Yu Austin Huang, Joel F. Studebaker, Anton Y...
BMCBI
2004
176views more  BMCBI 2004»
8 years 11 months ago
Boosting accuracy of automated classification of fluorescence microscope images for location proteomics
Background: Detailed knowledge of the subcellular location of each expressed protein is critical to a full understanding of its function. Fluorescence microscopy, in combination w...
Kai Huang, Robert F. Murphy
BMCBI
2004
130views more  BMCBI 2004»
8 years 11 months ago
PATTERNFINDER: combined analysis of DNA regulatory sequences and double-helix stability
Background: Regulatory regions that function in DNA replication and gene transcription contain specific sequences that bind proteins as well as less-specific sequences in which th...
Yanlin Huang, David Kowalski
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