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BMCBI
2004
127views more  BMCBI 2004»
9 years 1 months ago
MolTalk - a programming library for protein structures and structure analysis
Background: Two of the mostly unsolved but increasingly urgent problems for modern biologists are a) to quickly and easily analyse protein structures and b) to comprehensively min...
Alexander V. Diemand, Holger Scheib
BMCBI
2004
133views more  BMCBI 2004»
9 years 1 months ago
Evaluation of several lightweight stochastic context-free grammars for RNA secondary structure prediction
Background: RNA secondary structure prediction methods based on probabilistic modeling can be developed using stochastic context-free grammars (SCFGs). Such methods can readily co...
Robin D. Dowell, Sean R. Eddy
BMCBI
2004
79views more  BMCBI 2004»
9 years 1 months ago
A new mixture model approach to analyzing allelic-loss data using Bayes factors
Background: Allelic-loss studies record data on the loss of genetic material in tumor tissue relative to normal tissue at various loci along the genome. As the deletion of a tumor...
Manisha Desai, Mary J. Emond
BMCBI
2004
122views more  BMCBI 2004»
9 years 1 months ago
A comprehensive comparison of comparative RNA structure prediction approaches
Background: An increasing number of researchers have released novel RNA structure analysis and prediction algorithms for comparative approaches to structure prediction. Yet, indep...
Paul P. Gardner, Robert Giegerich
BMCBI
2004
119views more  BMCBI 2004»
9 years 1 months ago
Identification of polymorphic tandem repeats by direct comparison of genome sequence from different bacterial strains : a web-ba
Background: Polymorphic tandem repeat typing is a new generic technology which has been proved to be very efficient for bacterial pathogens such as B. anthracis, M. tuberculosis, ...
France Denoeud, Gilles Vergnaud
BMCBI
2004
146views more  BMCBI 2004»
9 years 1 months ago
Defining transcriptional networks through integrative modeling of mRNA expression and transcription factor binding data
Background: Functional genomics studies are yielding information about regulatory processes in the cell at an unprecedented scale. In the yeast S. cerevisiae, DNA microarrays have...
Feng Gao, Barrett C. Foat, Harmen J. Bussemaker
BMCBI
2004
154views more  BMCBI 2004»
9 years 1 months ago
Computation of elementary modes: a unifying framework and the new binary approach
Background: Metabolic pathway analysis has been recognized as a central approach to the structural analysis of metabolic networks. The concept of elementary (flux) modes provides ...
Julien Gagneur, Steffen Klamt
BMCBI
2004
81views more  BMCBI 2004»
9 years 1 months ago
Few amino acid positions in rpoB are associated with most of the rifampin resistance in Mycobacterium tuberculosis
Background: Mutations in rpoB, the gene encoding the subunit of DNA-dependent RNA polymerase, are associated with rifampin resistance in Mycobacterium tuberculosis. Several studi...
Michael P. Cummings, Mark R. Segal
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