BMCBI
2004
13 years 4 months ago
2004
Background: Expression microarrays are increasingly used to characterize environmental responses and hostparasite interactions for many different organisms. Probe selection for cD...
BMCBI
2004
13 years 4 months ago
2004
Background: Transcriptional regulation of cellular functions is carried out through a complex network of interactions among transcription factors and the promoter regions of genes...
BMCBI
2004
13 years 4 months ago
2004
Background: Several aspects of microarray data analysis are dependent on identification of genes expressed at or near the limits of detection. For example, regression-based normal...
BMCBI
2004
13 years 4 months ago
2004
Background: In addition to known protein-coding genes, large amounts of apparently non-coding sequence are conserved between the human and mouse genomes. It seems reasonable to as...
BMCBI
2004
13 years 4 months ago
2004
Background: Multiple sequence alignment algorithms are very important tools in molecular biology today. Accurate alignment of proteins is central to several areas such as homology...
BMCBI
2004
13 years 4 months ago
2004
Background: An increasing number of whole viral and bacterial genomes are being sequenced and deposited in public databases. In parallel to the mounting interest in whole genomes,...
BMCBI
2004
13 years 4 months ago
2004
Background: The Hotdog fold was initially identified in the structure of Escherichia coli FabA and subsequently in 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. strain CB...
BMCBI
2004
13 years 4 months ago
2004
Background: Rhabdomyosarcoma is a relatively common tumour of the soft tissue, probably due to regulatory disruption of growth and differentiation of skeletal muscle stem cells. I...
BMCBI
2004
13 years 4 months ago
2004
Background: All known genomes code for a large number of transcription factors. It is important to develop methods that will reveal how these transcription factors act on a genome...
BMCBI
2004
13 years 4 months ago
2004
Background: Annotation of sequences that share little similarity to sequences of known function remains a major obstacle in genome annotation. Some of the best methods of detectin...