BMCBI
2004
13 years 4 months ago
2004
Background: The functional selection and three-dimensional structural constraints of proteins in nature often relates to the retention of significant sequence similarity between p...
BMCBI
2004
13 years 4 months ago
2004
Background: There are two different theories about the development of the genetic code. Woese suggested that it was developed in connection with the amino acid repertoire, while C...
BMCBI
2004
13 years 4 months ago
2004
Background: This paper presents the use of Support Vector Machines (SVMs) for prediction and analysis of antisense oligonucleotide (AO) efficacy. The collected database comprises ...
BMCBI
2004
13 years 4 months ago
2004
Background: To identify differentially expressed genes across experimental conditions in oligonucleotide microarray experiments, existing statistical methods commonly use a summar...
BMCBI
2004
2004
Improving the scaling normalization for high-density oligonucleotide GeneChip expression microarrays
13 years 4 months ago
Background: Normalization is an important step for microarray data analysis to minimize biological and technical variations. Choosing a suitable approach can be critical. The defa...
BMCBI
2004
13 years 4 months ago
2004
Background: Modern biological research makes possible the comprehensive study and development of heritable mutations in the mouse model at high-throughput. Using techniques spanni...
BMCBI
2004
13 years 4 months ago
2004
BMCBI
2004
13 years 4 months ago
2004
Background: Tissue Microarrays (TMAs) have emerged as a powerful tool for examining the distribution of marker molecules in hundreds of different tissues displayed on a single sli...
BMCBI
2004
13 years 4 months ago
2004
Background Anatomy ontologies play an increasingly important role in developing integrated bioinformatics applications. One of the primary relationships between anatomical tissues...
BMCBI
2004
13 years 4 months ago
2004
Background: The increasing complexity of genomic data presents several challenges for biologists. Limited computer monitor views of data complexity and the dynamic nature of data ...