BMCBI
2005
13 years 4 months ago
2005
Background: Phages, viruses that infect prokaryotes, are the most abundant microbes in the world. A major limitation to studying these viruses is the difficulty of cultivating the...
BMCBI
2005
13 years 4 months ago
2005
Background: In a previous report (La et al., Proteins, 2005), we have demonstrated that the identification of phylogenetic motifs, protein sequence fragments conserving the overal...
BMCBI
2005
13 years 4 months ago
2005
Background: Detecting homology between remotely related protein families is an important problem in computational biology since the biological properties of uncharacterized protei...
BMCBI
2005
13 years 4 months ago
2005
Background: Searching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge ...
BMCBI
2005
13 years 4 months ago
2005
Background: Currently available methods to predict splice sites are mainly based on the independent and progressive alignment of transcript data (mostly ESTs) to the genomic seque...
BMCBI
2005
13 years 4 months ago
2005
Background: High throughput microarray analyses result in many differentially expressed genes that are potentially responsible for the biological process of interest. In order to ...
BMCBI
2005
13 years 4 months ago
2005
Background: Proteins carrying twin-arginine (Tat) signal peptides are exported into the periplasmic compartment or extracellular environment independently of the classical Secdepe...
BMCBI
2005
13 years 4 months ago
2005
Background: Periodic phenomena are widespread in biology. The problem of finding periodicity in biological time series can be viewed as a multiple hypothesis testing of the spectr...
BMCBI
2005
13 years 4 months ago
2005
Background: The process of oxidative folding combines the formation of native disulfide bond with conformational folding resulting in the native three-dimensional fold. Oxidative ...
BMCBI
2005
13 years 4 months ago
2005
Background: Regions of interest identified through genetic linkage studies regularly exceed 30 centimorgans in size and can contain hundreds of genes. Traditionally this number is...