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BMCBI
2005
167views more  BMCBI 2005»
8 years 10 months ago
Cross-platform analysis of cancer microarray data improves gene expression based classification of phenotypes
Background: The extensive use of DNA microarray technology in the characterization of the cell transcriptome is leading to an ever increasing amount of microarray data from cancer...
Patrick Warnat, Roland Eils, Benedikt Brors
BMCBI
2005
107views more  BMCBI 2005»
8 years 10 months ago
Protein subcellular localization prediction for Gram-negative bacteria using amino acid subalphabets and a combination of multip
Background: Predicting the subcellular localization of proteins is important for determining the function of proteins. Previous works focused on predicting protein localization in...
Jiren Wang, Wing-Kin Sung, Arun Krishnan, Kuo-Bin ...
BMCBI
2005
105views more  BMCBI 2005»
8 years 10 months ago
SNPHunter: a bioinformatic software for single nucleotide polymorphism data acquisition and management
Background: Single nucleotide polymorphisms (SNPs) provide an important tool in pinpointing susceptibility genes for complex diseases and in unveiling human molecular evolution. S...
Lin Wang, Simin Liu, Tianhua Niu, Xin Xu
BMCBI
2005
102views more  BMCBI 2005»
8 years 10 months ago
Genomic multiple sequence alignments: refinement using a genetic algorithm
Background: Genomic sequence data cannot be fully appreciated in isolation. Comparative genomics
Chunlin Wang, Elliot J. Lefkowitz
BMCBI
2005
135views more  BMCBI 2005»
8 years 10 months ago
A robust two-way semi-linear model for normalization of cDNA microarray data
Background: Normalization is a basic step in microarray data analysis. A proper normalization procedure ensures that the intensity ratios provide meaningful measures of relative e...
Deli Wang, Jian Huang, Hehuang Xie, Liliana Manzel...
BMCBI
2005
94views more  BMCBI 2005»
8 years 10 months ago
A method for finding single-nucleotide polymorphisms with allele frequencies in sequences of deep coverage
Background: The allele frequencies of single-nucleotide polymorphisms (SNPs) are needed to select an optimal subset of common SNPs for use in association studies. Sequence-based m...
Jianmin Wang, Xiaoqiu Huang
BMCBI
2005
86views more  BMCBI 2005»
8 years 10 months ago
Generalizations of Markov model to characterize biological sequences
Background: The currently used kth order Markov models estimate the probability of generating a single nucleotide conditional upon the immediately preceding (gap = 0) k units. How...
Junwen Wang, Sridhar Hannenhalli
BMCBI
2005
118views more  BMCBI 2005»
8 years 10 months ago
Vestige: Maximum likelihood phylogenetic footprinting
Background: Phylogenetic footprinting is the identification of functional regions of DNA by their evolutionary conservation. This is achieved by comparing orthologous regions from...
Matthew J. Wakefield, Peter Maxwell, Gavin A. Hutt...
BMCBI
2005
86views more  BMCBI 2005»
8 years 10 months ago
Chromosomal clustering of a human transcriptome reveals regulatory background
Background: There has been much evidence recently for a link between transcriptional regulation and chromosomal gene order, but the relationship between genomic organization, regu...
Jan H. Vogel, Anja von Heydebreck, Antje Purmann, ...
BMCBI
2005
98views more  BMCBI 2005»
8 years 10 months ago
InterferenceAnalyzer: Tools for the analysis and simulation of multi-locus genetic data
Background: Good statistical models for analyzing and simulating multilocus recombination data exist but are not accessible to many biologists because their use requires reasonabl...
Lalitha Viswanath, Elizabeth A. Housworth
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