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BMCBI
2006
86views more  BMCBI 2006»
13 years 4 months ago
Identification of QTLs controlling gene expression networks defined a priori
Background: Gene expression microarrays allow the quantification of transcript accumulation for many or all genes in a genome. This technology has been utilized for a range of inv...
Daniel J. Kliebenstein, Marilyn A. L. West, Hans v...
BMCBI
2006
131views more  BMCBI 2006»
13 years 4 months ago
inGeno - an integrated genome and ortholog viewer for improved genome to genome comparisons
Background: Systematic genome comparisons are an important tool to reveal gene functions, pathogenic features, metabolic pathways and genome evolution in the era of post-genomics....
Chunguang Liang, Thomas Dandekar
BMCBI
2006
95views more  BMCBI 2006»
13 years 4 months ago
Predicting DNA-binding sites of proteins from amino acid sequence
Background: Understanding the molecular details of protein-DNA interactions is critical for deciphering the mechanisms of gene regulation. We present a machine learning approach f...
Changhui Yan, Michael Terribilini, Feihong Wu, Rob...
BMCBI
2006
91views more  BMCBI 2006»
13 years 4 months ago
In silico identification of putative promoter motifs of White Spot Syndrome Virus
Background: White Spot Syndrome Virus, a member of the virus family Nimaviridae, is a large dsDNA virus infecting shrimp and other crustacean species. Although limited information...
Hendrik Marks, Xin-Ying Ren, Hans Sandbrink, Mari&...
BMCBI
2006
150views more  BMCBI 2006»
13 years 4 months ago
Cluster analysis of protein array results via similarity of Gene Ontology annotation
Background: With the advent of high-throughput proteomic experiments such as arrays of purified proteins comes the need to analyse sets of proteins as an ensemble, as opposed to t...
Cheryl Wolting, C. Jane McGlade, David Tritchler
BMCBI
2006
178views more  BMCBI 2006»
13 years 4 months ago
MannDB - A microbial database of automated protein sequence analyses and evidence integration for protein characterization
Background: MannDB was created to meet a need for rapid, comprehensive automated protein sequence analyses to support selection of proteins suitable as targets for driving the dev...
Carol L. Ecale Zhou, Marisa Lam, Jason Smith, Adam...
BMCBI
2006
75views more  BMCBI 2006»
13 years 4 months ago
A machine learning strategy to identify candidate binding sites in human protein-coding sequence
Background: The splicing of RNA transcripts is thought to be partly promoted and regulated by sequences embedded within exons. Known sequences include binding sites for SR protein...
Thomas Down, Bernard Leong, Tim J. P. Hubbard
BMCBI
2006
94views more  BMCBI 2006»
13 years 4 months ago
Simulation of microarray data with realistic characteristics
Background: Microarray technologies have become common tools in biological research. As a result, a need for effective computational methods for data analysis has emerged. Numerou...
Matti Nykter, Tommi Aho, Miika Ahdesmäki, Pek...
BMCBI
2006
156views more  BMCBI 2006»
13 years 4 months ago
Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple alignments
Background: Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, d...
Daniel A. Pollard, Alan M. Moses, Venky N. Iyer, M...