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BMCBI
2006
103views more  BMCBI 2006»
13 years 3 months ago
Accelerating the reconstruction of genome-scale metabolic networks
Background: The genomic information of a species allows for the genome-scale reconstruction of its metabolic capacity. Such a metabolic reconstruction gives support to metabolic e...
Richard A. Notebaart, Frank H. J. van Enckevort, C...
BMCBI
2006
128views more  BMCBI 2006»
13 years 3 months ago
New directions in biomedical text annotation: definitions, guidelines and corpus construction
Background: While biomedical text mining is emerging as an important research area, practical results have proven difficult to achieve. We believe that an important first step tow...
W. John Wilbur, Andrey Rzhetsky, Hagit Shatkay
BMCBI
2006
137views more  BMCBI 2006»
13 years 3 months ago
Bounded search for de novo identification of degenerate cis-regulatory elements
Background: The identification of statistically overrepresented sequences in the upstream regions of coregulated genes should theoretically permit the identification of potential ...
Jonathan M. Carlson, Arijit Chakravarty, Radhika S...
BMCBI
2006
130views more  BMCBI 2006»
13 years 3 months ago
An accurate and interpretable model for siRNA efficacy prediction
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...
BMCBI
2006
155views more  BMCBI 2006»
13 years 3 months ago
Analysis of promoter regions of co-expressed genes identified by microarray analysis
Background: The use of global gene expression profiling to identify sets of genes with similar expression patterns is rapidly becoming a widespread approach for understanding biol...
Srinivas Veerla, Mattias Höglund
BMCBI
2006
116views more  BMCBI 2006»
13 years 3 months ago
A model-based approach to selection of tag SNPs
Background: Single Nucleotide Polymorphisms (SNPs) are the most common type of polymorphisms found in the human genome. Effective genetic association studies require the identific...
Pierre Nicolas, Fengzhu Sun, Lei M. Li
BMCBI
2006
111views more  BMCBI 2006»
13 years 3 months ago
Tools for integrated sequence-structure analysis with UCSF Chimera
Background: Comparing related structures and viewing the structures in the context of sequence alignments are important tasks in protein structure-function research. While many pr...
Elaine C. Meng, Eric F. Pettersen, Gregory S. Couc...
BMCBI
2006
146views more  BMCBI 2006»
13 years 3 months ago
GeneTools - application for functional annotation and statistical hypothesis testing
Background: Modern biology has shifted from "one gene" approaches to methods for genomic-scale analysis like microarray technology, which allow simultaneous measurement ...
Vidar Beisvag, Frode K. R. Jünge, Hallgeir Be...
BMCBI
2006
117views more  BMCBI 2006»
13 years 3 months ago
A method for estimation of elasticities in metabolic networks using steady state and dynamic metabolomics data and linlog kineti
Background: Dynamic modeling of metabolic reaction networks under in vivo conditions is a crucial step in order to obtain a better understanding of the (dis)functioning of living ...
I. Emrah Nikerel, Wouter A. van Winden, Walter M. ...
BMCBI
2006
101views more  BMCBI 2006»
13 years 3 months ago
Predicting residue contacts using pragmatic correlated mutations method: reducing the false positives
Background: Predicting residues' contacts using primary amino acid sequence alone is an important task that can guide 3D structure modeling and can verify the quality of the ...
Petras J. Kundrotas, Emil Alexov