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123views Education» more  TITB 2010»
11 years 4 months ago
The pseudotemporal bootstrap for predicting glaucoma from cross-sectional visual field data
Progressive loss of the field of vision is characteristic of a number of eye diseases such as glaucoma, a leading cause of irreversible blindness in the world. Recently, there has ...
Allan Tucker, David Garway-Heath
233views Bioinformatics» more  JBI 2011»
11 years 4 months ago
A set of ontologies to drive tools for the control of vector-borne diseases
We are developing a set of ontologies that deal with vector-borne diseases and the arthropod vectors that transmit them. For practical reasons (application priorities), we initiat...
Pantelis Topalis, Emmanuel Dialynas, Elvira Mitrak...
11 years 4 months ago
Pathway-based analysis using reduced gene subsets in genome-wide association studies
Background: Single Nucleotide Polymorphism (SNP) analysis only captures a small proportion of associated genetic variants in Genome-Wide Association Studies (GWAS) partly due to s...
Jingyuan Zhao, Simone Gupta, Mark Seielstad, Jianj...
111views more  CARTOGRAPHICA 2010»
11 years 7 months ago
Essential, Illustrative, or ... Just Propaganda? Rethinking John Snow's Broad Street Map
For more than a century John Snow's iconic map of an 1854 cholera outbreak in the Broad Street area of Soho, London, has been the very definition of how to discover the sourc...
Tom Koch, Ken Denike
11 years 8 months ago
A Comorbidity Network Approach to Predict Disease Risk
A prediction model that exploits the past medical patient history to determine the risk of individuals to develop future diseases is proposed. The model is generated by using the s...
Francesco Folino, Clara Pizzuti, Maria Ventura
11 years 8 months ago
Boosting Alzheimer Disease Diagnosis Using PET Images
—Alzheimer’s disease (AD) final is one of the most frequent type of dementia. Currently there is no cure for AD and early diagnosis is crucial to the development of treatments...
Margarida Silveira, Jorge S. Marques
105views more  ARTMED 2000»
11 years 9 months ago
Planning treatment of ischemic heart disease with partially observable Markov decision processes
Diagnosis of a disease and its treatment are not separate, one-shot activities. Instead, they are very often dependent and interleaved over time. This is mostly due to uncertainty...
Milos Hauskrecht, Hamish S. F. Fraser
75views more  JIB 2007»
11 years 9 months ago
Mapping protein information to disease terminologies
In order to improve the accessibility of genomic and proteomic information to medical researchers, we have developed a procedure to link biological information on proteins involve...
Anaïs Mottaz, Yum Lina Yip, Patrick Ruch, Ann...
57views more  BMCBI 2005»
11 years 9 months ago
Satellog: A database for the identification and prioritization of satellite repeats in disease association studies
Background: To date, 35 human diseases, some of which also exhibit anticipation, have been associated with unstable repeats. Anticipation has been reported in a number of diseases...
Perseus I. Missirlis, Carri-Lyn R. Mead, Stefanie ...
100views more  BMCBI 2005»
11 years 9 months ago
Speeding disease gene discovery by sequence based candidate prioritization
Background: Regions of interest identified through genetic linkage studies regularly exceed 30 centimorgans in size and can contain hundreds of genes. Traditionally this number is...
Euan A. Adie, Richard R. Adams, Kathryn L. Evans, ...