JAMIA
2010
12 years 11 months ago
2010
Objective Lack of dose adjustment for renally cleared drugs in the presence of poor renal function is a common problem in the hospital setting. The absence of a clinical decision ...
NAR
2011
12 years 11 months ago
2011
The procedure of drug approval is time-consuming, costly and risky. Accidental findings regarding multispecificity of approved drugs led to block-busters in new indication areas. ...
NAR
2011
12 years 11 months ago
2011
Numerous genetic variations have been found to be related to human diseases. Significant portion of those affect the drug response as well by changing the protein structure and fu...
BMCBI
2010
12 years 11 months ago
2010
Background: The functional and structural characterisation of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design. The main inter...
AIME
2009
Springer
13 years 2 months ago
2009
Springer
Abstract. In pharmacovigilance, linking the adverse reactions by patients to drugs they took is a key activity typically based on the analysis of patient reports. Yet generating po...
NAR
2008
13 years 4 months ago
2008
The drug classification scheme of the World Health Organization (WHO) [Anatomical Therapeutic Chemical (ATC)-code] connects chemical classification and therapeutic approach. It is...
NAR
2008
13 years 4 months ago
2008
The molecular basis of drug action is often not well understood. This is partly because the very abundant and diverse information generated in the past decades on drugs is hidden ...
BMCBI
2010
13 years 4 months ago
2010
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...