94views more  JAMIA 2010»
9 years 20 days ago
Clinical decision support implemented with academic detailing improves prescribing of key renally cleared drugs in the hospital
Objective Lack of dose adjustment for renally cleared drugs in the presence of poor renal function is a common problem in the hospital setting. The absence of a clinical decision ...
Gregory W. Roberts, Christopher J. Farmer, Philip ...
244views Computer Vision» more  NAR 2011»
9 years 25 days ago
PROMISCUOUS: a database for network-based drug-repositioning
The procedure of drug approval is time-consuming, costly and risky. Accidental findings regarding multispecificity of approved drugs led to block-busters in new indication areas. ...
Joachim von Eichborn, Manuela S. Murgueitio, Mathi...
227views Computer Vision» more  NAR 2011»
9 years 25 days ago
VnD: a structure-centric database of disease-related SNPs and drugs
Numerous genetic variations have been found to be related to human diseases. Significant portion of those affect the drug response as well by changing the protein structure and fu...
Jin Ok Yang, Sangho Oh, Gunhwan Ko, Seong-Jin Park...
148views more  BMCBI 2010»
9 years 27 days ago
SKPDB: a structural database of shikimate pathway enzymes
Background: The functional and structural characterisation of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design. The main inter...
Helen A. Arcuri, Geraldo F. D. Zafalon, Evandro A....
9 years 3 months ago
Mining Safety Signals in Spontaneous Reports Database Using Concept Analysis
Abstract. In pharmacovigilance, linking the adverse reactions by patients to drugs they took is a key activity typically based on the analysis of patient reports. Yet generating po...
Mohamed Rouane Hacene, Yannick Toussaint, Petko Va...
116views more  NAR 2008»
9 years 5 months ago
SuperPred: drug classification and target prediction
The drug classification scheme of the World Health Organization (WHO) [Anatomical Therapeutic Chemical (ATC)-code] connects chemical classification and therapeutic approach. It is...
Mathias Dunkel, Stefan Günther, Jessica Ahmed...
118views more  NAR 2008»
9 years 5 months ago
SuperTarget and Matador: resources for exploring drug-target relationships
The molecular basis of drug action is often not well understood. This is partly because the very abundant and diverse information generated in the past decades on drugs is hidden ...
Stefan Günther, Michael Kuhn 0004, Mathias Du...
133views more  BMCBI 2010»
9 years 6 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang