Sciweavers

BIOCOMP
2008
13 years 5 months ago
Discoveries in shRNA Design
-- To successfully apply RNAi, the very first step is to design functional siRNA or shRNA sequences targeting specific genes. Many characteristics of functional synthetic siRNAs ha...
Hong Zhou, Xiao Zeng, Joseph Manthey
BIBM
2008
IEEE
105views Bioinformatics» more  BIBM 2008»
13 years 10 months ago
Energy Profile and Secondary Structure Impact shRNA Efficacy
Many characteristics of functional synthetic siRNAs have been identified. Our three-phase algorithm was developed to design siRNA on a wholegenome scale based on these characteris...
Hong Zhou, Xiao Zeng