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10 years 4 months ago
Haplotype Reconstruction in Large Pedigrees with Many Untyped Individuals
Abstract. Haplotypes, as they specify the linkage patterns between dispersed genetic variations, provide important information for understanding the genetics of human traits. Howev...
Xin Li, Jing Li
10 years 8 months ago
SNP-based pathway enrichment analysis for genome-wide association studies
Background: Recently we have witnessed a surge of interest in using genome-wide association studies (GWAS) to discover the genetic basis of complex diseases. Many genetic variatio...
Lingjie Weng, Fabio Macciardi, Aravind Subramanian...
227views Computer Vision» more  NAR 2011»
10 years 8 months ago
VnD: a structure-centric database of disease-related SNPs and drugs
Numerous genetic variations have been found to be related to human diseases. Significant portion of those affect the drug response as well by changing the protein structure and fu...
Jin Ok Yang, Sangho Oh, Gunhwan Ko, Seong-Jin Park...
10 years 11 months ago
A Data Mining Approach for the Detection of High-Risk Breast Cancer Groups
It is widely agreed that complex diseases are typically caused by the joint effects of multiple instead of a single genetic variation. These genetic variations may show very little...
Orlando Anunciação, Bruno C. Gomes, ...
127views more  BMCBI 2007»
11 years 1 months ago
Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines
Background: Human genetic variations primarily result from single nucleotide polymorphisms (SNPs) that occur approximately every 1000 bases in the overall human population. The no...
Jian Tian, Ningfeng Wu, Xuexia Guo, Jun Guo, Juhua...
149views more  BMCBI 2010»
11 years 1 months ago
A multifactorial analysis of obesity as CVD risk factor: Use of neural network based methods in a nutrigenetics context
Background: Obesity is a multifactorial trait, which comprises an independent risk factor for cardiovascular disease (CVD). The aim of the current work is to study the complex eti...
Ioannis K. Valavanis, Stavroula G. Mougiakakou, Ke...
11 years 6 months ago
Haplotype Motifs: An Algorithmic Approach to Locating Evolutionarily Conserved Patterns in Haploid Sequences
The promise of plentiful data on common human genetic variations has given hope that we will be able to uncover genetic factors behind common diseases that have proven dif´Čücult ...
Russell Schwartz