BMCBI
2011
12 years 11 months ago
2011
Background: It has been suggested previously that genome and proteome sequences show characteristics typical of natural-language texts such as “signature-style” word usage ind...
BMCBI
2010
12 years 11 months ago
2010
Background: A new paradigm of biological investigation takes advantage of technologies that produce large high throughput datasets, including genome sequences, interactions of pro...
BCB
2010
12 years 11 months ago
2010
Recent studies suggest that the mammalian genomes can be subdivided in segments within which there is limited haplotype diversity. Understanding the distribution and structure of ...
BMCBI
2010
13 years 2 months ago
2010
Background: Physical maps are the substrate of genome sequencing and map-based cloning and their construction relies on the accurate assembly of BAC clones into large contigs that...
BIB
2010
13 years 2 months ago
2010
Genome-wide sequencing has enabled modern biomedical research to relate more and more events in healthy as well as disease-affected cells and tissues to the genomic sequence. Now ...
IPPS
2010
IEEE
13 years 2 months ago
2010
IEEE
Millions of DNA sequences (reads) are generated by Next Generation Sequencing machines everyday. There is a need for high performance algorithms to map these sequences to the refer...
GCB
2010
Springer
13 years 2 months ago
2010
Springer
: The current high-throughput sequencing technologies produce gigabytes of data even when prokaryotic genomes are processed. In a subsequent assembly phase, the generated overlappi...
BMCBI
2010
13 years 2 months ago
2010
Background: A common approach to understanding the genetic basis of complex traits is through identification of associated quantitative trait loci (QTL). Fine mapping QTLs require...
RECOMB
2010
Springer
13 years 2 months ago
2010
Springer
An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Althou...