BMCBI
2008
13 years 4 months ago
2008
Background: It has been repeatedly observed that gene order is rapidly lost in prokaryotic genomes. However, persistent synteny blocks are found when comparing more or less distan...
BMCBI
2008
13 years 4 months ago
2008
Background: The recent availability of complete sequences for numerous closely related bacterial genomes opens up new challenges in comparative genomics. Several methods have been...
BMCBI
2007
13 years 4 months ago
2007
Background: Genome assemblers have grown very large and complex in response to the need for algorithms to handle the challenges of large whole-genome sequencing projects. Many of ...
BMCBI
2008
13 years 4 months ago
2008
Background: The conservation of gene order among prokaryotic genomes can provide valuable insight into gene function, protein interactions, or events by which genomes have evolved...
BMCBI
2008
13 years 4 months ago
2008
Background: Mining gene patterns that are common to multiple genomes is an important biological problem, which can lead us to novel biological insights. When family classification...
BMCBI
2008
13 years 4 months ago
2008
Background: The process of horizontal gene transfer (HGT) is believed to be widespread in Bacteria and Archaea, but little comparative data is available addressing its occurrence ...
BMCBI
2008
13 years 4 months ago
2008
Background: Modern proteomes evolved by modification of pre-existing ones. It is extremely important to comparative biology that related proteins be identified as members of the s...
BMCBI
2008
13 years 4 months ago
2008
Background: Genomic islands (GIs) are clusters of genes in prokaryotic genomes of probable horizontal origin. GIs are disproportionately associated with microbial adaptations of m...
BMCBI
2008
13 years 4 months ago
2008
Background: While the C. elegans genome is extensively annotated, relatively little information is available for other Caenorhabditis species. The nematode genome annotation asses...
BMCBI
2008
13 years 4 months ago
2008
Background: Analysis of sequence composition is a routine task in genome research. Organisms are characterized by their base composition, dinucleotide relative abundance, codon us...