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JCB
2000
103views more  JCB 2000»
13 years 3 months ago
Testing for Differentially-Expressed Genes by Maximum-Likelihood Analysis of Microarray Data
Although two-color uorescent DNA microarrays are now standard equipment in many molecular biology laboratories, methods for identifying differentially expressed genes in microarra...
Trey Ideker, Vesteinn Thorsson, Andrew F. Siegel, ...
JCB
2000
55views more  JCB 2000»
13 years 3 months ago
Systematic and Fully Automated Identification of Protein Sequence Patterns
Reece Hart, Ajay K. Royyuru, Gustavo Stolovitzky, ...
JCB
2000
101views more  JCB 2000»
13 years 3 months ago
Evaluation Measures of Multiple Sequence Alignments
Multiple sequence alignments (MSAs) are frequently used in the study of families of protein sequences or DNA/RNA sequences. They are a fundamental tool for the understanding of th...
Gaston H. Gonnet, Chantal Korostensky, Steven A. B...
JCB
2000
129views more  JCB 2000»
13 years 3 months ago
Prediction of RNA Base Pairing Probabilities on Massively Parallel Computers
We present an implementation of McCaskill's algorithm for computing the base pair probabilities of an RNA molecule for massively parallel message passing architectures. The p...
Martin Fekete, Ivo L. Hofacker, Peter F. Stadler
JCB
2000
71views more  JCB 2000»
13 years 3 months ago
Structure Comparison and Structure Patterns
This article investigates aspects of pairwise and multiple structure comparison, and the problem of automatically discover common patterns in a set of structures. Descriptions and...
Ingvar Eidhammer, Inge Jonassen, William R. Taylor
JCB
2000
91views more  JCB 2000»
13 years 3 months ago
Scaling Laws and Similarity Detection in Sequence Alignment with Gaps
We study the problem of similarity detection by sequence alignment with gaps, using a recently established theoretical framework based on the morphology of alignment paths. Alignm...
Dirk Drasdo, Terence Hwa, Michael Lässig
JCB
2000
59views more  JCB 2000»
13 years 3 months ago
Efficient Detection of Unusual Words
Alberto Apostolico, Mary Ellen Bock, Stefano Lonar...
JCB
2000
137views more  JCB 2000»
13 years 3 months ago
NOTUNG: A Program for Dating Gene Duplications and Optimizing Gene Family Trees
Large scale gene duplication is a major force driving the evolution of genetic functional innovation. Whole genome duplications are widely believed to have played an important rol...
Kevin Chen, Dannie Durand, Martin Farach-Colton