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NAR
2006
177views more  NAR 2006»
11 years 8 months ago
PUMA2 - grid-based high-throughput analysis of genomes and metabolic pathways
The PUMA2 system (available at http://compbio.mcs. 10 anl.gov/puma2) is an interactive, integrated bioinformatics environment for high-throughput genetic sequence analysis and met...
Natalia Maltsev, Elizabeth M. Glass, Dinanath Sula...
BMCBI
2006
103views more  BMCBI 2006»
11 years 8 months ago
Accelerating the reconstruction of genome-scale metabolic networks
Background: The genomic information of a species allows for the genome-scale reconstruction of its metabolic capacity. Such a metabolic reconstruction gives support to metabolic e...
Richard A. Notebaart, Frank H. J. van Enckevort, C...
BMCBI
2006
92views more  BMCBI 2006»
11 years 8 months ago
Systematic assignment of thermodynamic constraints in metabolic network models
Background: The availability of genome sequences for many organisms enabled the reconstruction of several genome-scale metabolic network models. Currently, significant efforts are...
Anne Kümmel, Sven Panke, Matthias Heinemann
BMCBI
2006
125views more  BMCBI 2006»
11 years 8 months ago
Algebraic comparison of metabolic networks, phylogenetic inference, and metabolic innovation
Metabolic networks are naturally represented as directed hypergraphs in such a way that metabolites are nodes and enzyme-catalyzed reactions form (hyper)edges. The familiar operat...
Christian V. Forst, Christoph Flamm, Ivo L. Hofack...
BMCBI
2008
129views more  BMCBI 2008»
11 years 8 months ago
An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments
Background: Metabolic fluxes provide invaluable insight on the integrated response of a cell to environmental stimuli or genetic modifications. Current computational methods for e...
Ari Rantanen, Juho Rousu, Paula Jouhten, Nicola Za...
BMCBI
2010
133views more  BMCBI 2010»
11 years 8 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
BMCBI
2008
117views more  BMCBI 2008»
11 years 8 months ago
Using a logical model to predict the growth of yeast
Background: A logical model of the known metabolic processes in S. cerevisiae was constructed from iFF708, an existing Flux Balance Analysis (FBA) model, and augmented with inform...
Ken E. Whelan, Ross D. King
BMCBI
2010
114views more  BMCBI 2010»
11 years 8 months ago
Detecting variants with Metabolic Design, a new software tool to design probes for explorative functional DNA microarray develop
Background: Microorganisms display vast diversity, and each one has its own set of genes, cell components and metabolic reactions. To assess their huge unexploited metabolic poten...
Sébastien Terrat, Eric Peyretaillade, Olivi...
BMCBI
2008
142views more  BMCBI 2008»
11 years 8 months ago
Identification of biomarkers for genotyping Aspergilli using non-linear methods for clustering and classification
Background: In the present investigation, we have used an exhaustive metabolite profiling approach to search for biomarkers in recombinant Aspergillus nidulans (mutants that produ...
Irene Kouskoumvekaki, Zhiyong Yang, Svava Ó...
BMCBI
2008
153views more  BMCBI 2008»
11 years 8 months ago
Estimating the size of the solution space of metabolic networks
Background: Cellular metabolism is one of the most investigated system of biological interactions. While the topological nature of individual reactions and pathways in the network...
Alfredo Braunstein, Roberto Mulet, Andrea Pagnani
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