BMCBI
2008
13 years 4 months ago
2008
Background: Multivariate ordination methods are powerful tools for the exploration of complex data structures present in microarray data. These methods have several advantages com...
BMCBI
2008
13 years 4 months ago
2008
Background: The accurate detection of differentially expressed (DE) genes has become a central task in microarray analysis. Unfortunately, the noise level and experimental variabi...
BMCBI
2008
13 years 4 months ago
2008
Background: Microarray technology provides an efficient means for globally exploring physiological processes governed by the coordinated expression of multiple genes. However, ide...
BMCBI
2008
13 years 4 months ago
2008
Background: Normalization is essential in dual-labelled microarray data analysis to remove nonbiological variations and systematic biases. Many normalization methods have been use...
BMCBI
2010
13 years 4 months ago
2010
Background: Visualization of DNA microarray data in two or three dimensional spaces is an important exploratory analysis step in order to detect quality issues or to generate new ...
BMCBI
2007
13 years 4 months ago
2007
Background: Large-scale sequencing of entire genomes has ushered in a new age in biology. One of the next grand challenges is to dissect the cellular networks consisting of many i...
BMCBI
2008
13 years 4 months ago
2008
Background: Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical...
BMCBI
2010
13 years 4 months ago
2010
Background: Much of the public access cancer microarray data is asymmetric, belonging to datasets containing no samples from normal tissue. Asymmetric data cannot be used in stand...
BMCBI
2010
13 years 4 months ago
2010
Background: Microarray experiments have become very popular in life science research. However, if such experiments are only considered independently, the possibilities for analysi...
BMCBI
2007
13 years 4 months ago
2007
Background: During generation of microarray data, various forms of systematic biases are frequently introduced which limits accuracy and precision of the results. In order to prop...