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NAR
1998
86views more  NAR 1998»
13 years 4 months ago
Pfam: multiple sequence alignments and HMM-profiles of protein domains
Pfam contains multiple alignments and hidden Markov model based profiles (HMM-profiles) of complete protein domains. The definition of domain boundaries, family members and alignm...
Erik L. L. Sonnhammer, Sean R. Eddy, Ewan Birney, ...
BMCBI
2007
104views more  BMCBI 2007»
13 years 5 months ago
Predicting active site residue annotations in the Pfam database
Background: Approximately 5% of Pfam families are enzymatic, but only a small fraction of the sequences within these families (<0.5%) have had the residues responsible for cata...
Jaina Mistry, Alex Bateman, Robert D. Finn