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BMCBI
2010
160views more  BMCBI 2010»
10 years 2 months ago
Identification of functional hubs and modules by converting interactome networks into hierarchical ordering of proteins
Background: Protein-protein interactions play a key role in biological processes of proteins within a cell. Recent high-throughput techniques have generated protein-protein intera...
Young-Rae Cho, Aidong Zhang
BMCBI
2010
80views more  BMCBI 2010»
10 years 2 months ago
An ontology-based search engine for protein-protein interactions
Background: Keyword matching or ID matching is the most common searching method in a large database of protein-protein interactions. They are purely syntactic methods, and retriev...
Byungkyu Park, Kyungsook Han
SNPD
2004
10 years 4 months ago
Prediction of Protein Dispensability through Integrated Analysis of Multiple-Source High-Throughput Data
Protein dispensability is fundamental to understanding of gene function and evolution. It is usually studied at the individual gene phenotype level. Recent advances in generating ...
Yu Chen, Dong Xu
EVOW
2008
Springer
10 years 4 months ago
Protein Interaction Inference Using Particle Swarm Optimization Algorithm
Many processes in the cell involve interaction among the proteins and determination of the networks of such interactions is of immense importance towards the complete understanding...
Mudassar Iqbal, Alex Alves Freitas, Colin G. Johns...
GCC
2006
Springer
10 years 6 months ago
Grid Enabled Data Integration Framework for Bioinformatics Research
A framework is proposed to manage the distributed and heterogeneous databases in grid environment for understanding protein-protein interaction. Furthermore, the framework is used...
Jia Liu, Yongwei Wu, Weimin Zheng
BICOB
2009
Springer
10 years 6 months ago
Constrained Fisher Scores Derived from Interaction Profile Hidden Markov Models Improve Protein to Protein Interaction Predictio
Protein-protein interaction plays critical roles in cellular functions. In this work, we propose a computational method to predict protein-protein interaction by using support vec...
Alvaro J. González, Li Liao
CSB
2002
IEEE
230views Bioinformatics» more  CSB 2002»
10 years 7 months ago
Prediction of Protein Function Using Protein-Protein Interaction Data
Assigning functions to novel proteins is one of the most important problems in the post-genomic era. Several approaches have been applied to this problem, including analyzing gene...
Minghua Deng, Kui Zhang, Shipra Mehta, Ting Chen, ...
GRC
2005
IEEE
10 years 8 months ago
Visualization of protein-protein interaction network for knowledge discovery
A new visualization tool, called "Visual Concept Explorer (VCE)", was developed to visualize concept relationships in bio-medical literatura VCE integrates Pathfinder Net...
Weizhong Zhu, Xia Lin, Xiaohua Hu, Bahrad A. Sokha...
CSB
2005
IEEE
118views Bioinformatics» more  CSB 2005»
10 years 8 months ago
A Protein Interaction Verification System Based on a Neural Network Algorithm
Large amounts of protein-protein interaction data have been identified using various genome-scale screening techniques. Although interaction data is a valuable resource, high-thro...
Min Su Lee, Seung-Soo Park, Min Kyung Kim
BIBE
2005
IEEE
154views Bioinformatics» more  BIBE 2005»
10 years 8 months ago
Effective Pre-Processing Strategies for Functional Clustering of a Protein-Protein Interactions Network
In this article we present novel preprocessing techniques, based on topological measures of the network, to identify clusters of proteins from Protein-protein interaction (PPI) ne...
Duygu Ucar, Srinivasan Parthasarathy, Sitaram Asur...
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